Human Growth Hormone Terminology

Somatotropin / Somatotrophin
Scientific name for human growth hormone.

Growth Hormone
Common name for human growth hormone.

GH
Abbreviation for Growth Hormone (human growth hormone).

Somatropin
Scientific name for synthetic human growth hormone created by protein secretion technology or mouse-cell technology.

Human Growth Hormone
A protein produced in the pituitary gland that stimulates the liver to produce somatomedins, which stimulate growth of bone and muscle. HGH stays in the bloodstream for only a few minutes. However, this is long enough to stimulate its uptake by the liver, causing the production of Insulin-like growth factor-1. Human growth hormone is the most abundant hormone produced by the pituitary gland in the brain. It peaks during the rapid-growth phase of adolescence, then steadily declines with age.

HGH
Abbreviation for synthetic human growth hormone

rhGH
Abbreviation for recombinant human growth hormone, same as somatropin.

Somatrem
Somatrem is a synthetic GH protein that contains an additional methionine amino acid, which has been added to the 24-amino acid initiation sequence. Natural (endogenous) humanngrowth hormone is a polypeptide containing 191 amino acids. Somatrem has a 192 amino acid sequence. In the human body it works similar as real HGH, but may cause the body to build up anti bodies, thus causing a number of unwanted side effects.

rBST
Abbreviation for recombinant bovine somatropin.

met-GH
Abbreviation for methionyl-growth hormone.

GHD
Abbreviation for growth hormone deficiency.

Somatopause
Like female menopause, the fall in growth hormone (somatotrophin) is predictable, and the effects profound. Two differences between growth hormone decline and estrogen decline are rate and reversibility. Whereas estrogen drops like a stone, growth hormone descends slowly, taking other hormones, and your youthfulness, with it. And while the estrogen drop is unavoidable by natural means, growth hormone decline is now more a matter of choice than a fact of human destiny. For this reason, it has been given a similar name, "Somatopause."

Pituitary gland
A small gland attached by a stalk to the base of the brain (it is sometimes called the "master gland."). It secretes hormones that control other glands and regulate growth.

Metabolism
The chemical and physical processes continuously occurring in the body and its cells, such as when foods are turned into energy, tissue, or waste products.

Pediatric growth hormone deficiency
Growth hormone deficiency during infancy or childhood. It occurs when the production of growth hormone by the pituitary gland is disrupted. This results in abnormalities of many body processes, including growth and development, production of muscle protein, and breakdown of fats. Although this condition is uncommon, it may occur at any time during infancy or childhood, and there are many possible causes.

PGHD
Pediatric growth hormone deficiency. See above.

Syndrome
A set of features or symptoms often occurring together and believed to stem from the same cause.

Synthesize
To create something, such as chemicals in the body, from simpler, raw materials.

Adult Growth Hormone Deficiency
Growth hormone deficiency during adulthood. Adults need growth hormone to maintain healthy body composition and metabolism. This condition occurs when the pituitary gland either is missing or does not secrete enough growth hormone. It may be the continuation of a growth hormone deficiency that began in infancy or childhood (childhood-onset AGHD), or it may begin in adulthood (adult-onset AGHD).

AGHD
Adult Growth Hormone Deficiency. Growth hormone deficiency during adulthood.

Adult-onset AGHD
Adult Growth Hormone Deficiency which begins in Adulthood.

Amino Acid
The molecules that form the building blocks of proteins. Although several dozen other amino acids are found in nature, most organisms construct proteins from a particular set of 20 amino acids.

Inclusion Body Technology
The biosynthetic process used to make somatrem, also called the Inclusion Body Process, involves the chemical synthesis of the DNA fragment encoding the first 24 amino acids. The remaining amino acid residues are obtained by making complimentary DNA copies of messenger RNA prepared from human pituitary cells.

E.Coli
E. coli is the abbreviated name of the bacterium in the Family Enterobacteriaceae named Escherichia (Genus) coli (Species). E. coli, along with other species of bacteria, provide us with many necessary vitamins for example. The bacteria make the vitamins, and we gladly absorb them. We pretty much depend upon E. coli in our intestines for our source of Vitamin K and B-complex vitamins. Special strain of E.Coli bacteria is genetically engineered to produce Human Growth Hormone.

Secretion Technology
Protein secretion technology is an improved alternative to production in e-coli, in which the rhGh is secreted in a protein-free production media.Manufacturing a recombinant protein like human growth hormone by secretion is done by adding a leader of secretory sequence (usually a sequence of a cytokine) onto the n-terminal (nitrogenterminal) of the growth hormone amino acid chain. That allows the recombinant protein to be secreted, facilitating a simpler purification process,and avoiding resolubisation of inclusion bodies and protein refolding.